That second-line designation could change, however, when results of a large phase 3 trial, Checkmate-459, come in, Abou-Alfa says; the trial is considering whether Opdivo might be more effective than Nexavar in the firstline setting. “This has been an incredible year and positive time regarding our therapies for (patients with) liver cancer,” says Ghassan K. Abou-Alfa, M.D., a medical oncologist at Memorial Sloan Kettering Cancer Center in New York City. "We have found that many of our discoveries are helping grow the pipeline of novel diagnostics and therapeutics available to patients here and around the world,” said Mark Pimentel, MD, director of the Medically Associated Science and Technology (MAST) Program. “We’ll see that phase 3 trial soon. In the past, the experimental drug tivantinib, which also inhibits c-MET, did not prove effective when compared with placebo in c-MET-positive patients with liver cancer. Nexavar was “the first systemic therapy with a survival benefit for HCC,” according to Amit G. Singal, M.D., associate professor of internal medicine and medical director of the Parkland Liver Tumor Program at University of Texas Southwestern Medical Center in Dallas. Other common side effects included pain, decreased appetite, infection, dysphonia (a voice control problem), elevated bilirubin (which can indicate a liver problem), fever, mucositis (ulceration of the lining of the digestive tract), weight loss, rash and nausea. “It is an impressive effort,” he continues, “but the other thing that will have a lot of potential, though we haven’t seen any data yet, will be CAR (chimeric antigen receptor)-T cell therapy.” This involves removing immune cells from patients, engineering them to recognize and kill cancer cells associated with specific proteins, and reinfusing the powerful T cells. The most common serious or severe side effects with both drugs were hypertension, decreased weight, decreased platelet count, elevated aspartate aminotransferase indicating potential liver damage, decreased appetite, diarrhea and hand-foot skin reaction. A different class of drug was approved in September 2017. In the phase 2 trial, the most common side effects overall with Opdivo were itchiness, fatigue, rash and diarrhea. “Creeping Fat” around intestines of IBD patients: Most Crohn’s disease patients develop what is known as “creeping fat” around sites of inflammation in the intestines. Mobile Health and Food Symptom Tracker: Researchers tested a new questionnaire called the Food and Symptom Tracker (FAST) and successfully validated it against existing measures. “We have been trying for the past 10 years to see how we can improve on the outcome of sorafenib by trying different things — going into combination therapies or even looking at second-line therapy. 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