Ondansetron, sold under the brand name Zofran, is typically used to treat nausea and vomiting after surgery, cancer chemotherapy, or radiation. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. Giant Hives 10. Potential pregnancy side effects of Zofran have been linked to an increased risk of unborn babies developing serious … [Ref], Common (1% to 10%): Sensation of warmth/flushing, bradycardia, hypotension, arrhythmias, Uncommon (0.1% to 1%): Chest pain with/without ST segment depression, Rare (0.01% to 0.1%): Transient ECG changes including QT interval prolongation (Torsade de Pointes), angina/chest pain, vascular occlusive events, tachycardia, Postmarketing reports: Cardiopulmonary arrest, shock[Ref], Common (1% to 10%): Hypoxia, lower respiratory tract disease, expectoration, cough, Rare (0.01% to 0.1%): Bronchospasm/asthma, Postmarketing reports: Shortness of breath, laryngeal edema, stridor, laryngospasm[Ref], Laryngospasm occurred during allergic reactions in patients given the IV formulation. The most concerning side effects of Zofran include effects on the heart rhythm, a potential for birth defects and a condition known as serotonin syndrome. We comply with the HONcode standard for trustworthy health information -. While there are many types of patients who shouldn't take Zofran, some patients who would otherwise benefit from the medication can suffer side effects due to […] In fact, along with the risks of birth defects in their infants, other side effects that directly affect the mother include: Many pregnant women have relied on anti-nausea medications to get them through the first few months of pregnancy, when nausea is at its peak. Zofran is linked to possible side effects, some of which are serious, including serotonin syndrome and QT interval prolongation. Cerner Multum, Inc. "Australian Product Information." Note: This document contains side effect information about ondansetron. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. difficulty with passing urine (dribbling), puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, increased blinking or spasms of the eyelid, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, uncontrolled twisting movements of the neck, trunk, arms, or legs, difficulty having a bowel movement (stool), uncontrolled movements, especially of the face, neck, and back, redness of the face, neck, arms, and occasionally, upper chest. Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Acute Liver Failure 5. All medications have side effects, including Zofran. Ondansetron orally disintegrating tablet may cause drowsiness. Ondansetron is a common medication that can be used to treat vomiting in dogs and cats. Most patients were receiving concomitant chemotherapy with cisplatin. Applies to ondansetron: film, solution, tablet, tablet disintegrating. The more common side effects of ondansetron can include: Doctors also prescribe it to pregnant women who have extreme or debilitating morning sickness. Bronchospasm 6. There are no adequate studies of Zofran in pregnant women to determine its safe and effective use during pregnancy. Selected from data included with permission and copyrighted by First Databank, Inc. Zofran (ondansetron)." A myriad of women have come forward after experiencing adverse effects after taking the medication. It is unknown if Zofran enters breast milk. Slow Heartbeat 14. SIDE EFFECTS: Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. If these effects persist or worsen, notify your doctor promptly. It is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. [Ref], Common (1% to 10%): Injection site reactions[Ref], Rare (0.01% to 0.1%): Immediate hypersensitivity reactions (sometimes severe), anaphylaxis/anaphylactoid reactions, Frequency not reported: Poor oral intake[Ref], 1. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Transient visual disturbances, blurred vision, and transient blindness occurred predominantly during rapid IV administration. Last updated on Nov 11, 2020. Oculogyric crisis occurred alone and in combination with other dystonic reactions. Many of the cases of blindness resolved from within a few minutes to approximately 28 hours. Toxic Epidermal Necrolysis 17. What Are Side Effects of Zofran? Common side effects associated with Zofran include headache, drowsiness, constipation and the chills. The National Institutes of Health lists the following as common side effects. Unlike some other nausea medicines, the side effects for Zofran (ondansetron… This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It’s a drug that blocks the action of serotonin, a naturally occurring substance that can lead to nausea and vomiting. The effects of Zofran were never investigated in clinical trials that included pregnant women, and thus there are no clinical trials targeting pregnant women that would provide us with a way of knowing what side effects it may cause in them or harm it may do to developing babies. In the ondansetron prescribing label information (Zofran®, Zofran ODT® package insert), the most commonly reported ondansetron (Zofran®, Zofran ODT®) side effects are shown here. Some side effects may not be reported. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. Applies to ondansetron: film, solution, tablet, tablet disintegratingOther dosage forms: 1. injection solutionAlong with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Check with your doctor immediately if any of the following side effects occur while taking ondansetron: Some side effects of ondansetron may occur that usually do not need medical attention. O 0. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Have come forward after experiencing adverse effects after taking the medication of treatment with other dystonic.. Blindness resolved from within a few minutes to approximately 28 hours and pharmacy coupons can help offset the cost and... No adequate studies of Zofran in pregnant women to determine its safe and use. 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